放疗后加DF化疗方案治疗食管癌

Chemotherapy with DF project in postradiotherapy period for esophageal carcinoma patients.

目的探讨放疗后辅以 DF(DDP 顺铂,5-FU 氟尿嘧啶)方案化疗对食管癌的治疗价值。方法 192例食管癌患者随机被分为两组:甲组(综合治疗组,放疗后辅以 DF 方案化疗)和乙组(单纯放疗组)。两组均作随访3年。结果甲组的1、2、3年生存率分别为61.5%、44.8%、34.3%,乙组分别为45.8%、31.3%、18.8%。综合治疗组的生存率显著高于单纯放疗组(P<0.05)。病灶局部未控制或复发率在综合治疗组为45.8%,在单纯放疗组为52.1%,两组间无显著性差异(P>0.05);癌的远处转移发生率在综合治疗组为5.2%,在单纯放疗组为16.7%,两组间的差异有显著性(P<0.05);放疗后晚期食管受损情况在综合组为34.4%,在单纯放疗组为17.7%,两组间差异显著(P<0.005)。结论放疗后加 DF 方案化疗对食管癌有较好的疗效,值得临床进一步探索和应用。

Objective To study the therapeutic effect of chemotherapy with DF project after radiotherapy for esophageal carcinoma patients.Methods 192 cases of esophageal cancer were randomly allocated into two groups:Group one(received chemotherapy with DF project after radiotherapy)and Group two(received radiotherapy only).Both groups were followed up for a period of three years.Results Survival rates for 1,2 and 3 years in group one was much higher than that in group two(P<0.05).The lo- cal tumor control of the two groups had no significant difference(P<0.05);but there were significant difference in the metastasis between the two groups,the metastasis occurrence rate in group one was much lower than that in group two(P<0.05);The radi- ation injury to the esophagus in group one was much higher in occurrence than that in group two(P<0.005).Conclusion Chemotherapy with DF project after radiotherapy for esophageal carcinoma patients has much better effect