摘要
目的研究乙型肝炎患者的肝窦病变的体视学指标及它与肝组织病变的关系。方法应用体视学分析技术对300型乙型肝炎肝活检标本及10例正常肝组织的肝窦组织进行形态学观察,并测定其肝窦个数、总面积、平均直径。结果与正常组相比,急性肝炎组的上述各参数均明显减少(P<0.01);慢性乙型肝炎轻、中两组的各参数变化不大(P>0.05)。慢性乙型肝炎重及慢性乙型肝炎后肝硬变组的肝窦个数明显减小,总面积、平均直径皆明显增大(P 均<0.01),且均以慢性乙型肝炎谷肝硬变的各参数变化最大。结论体视学分析技术对这些参数能提供量化指标,对正确分析肝病患者肝内微循环状况有重要的指导意义。
Objective To study the stereological indexes of hepatic sinusoidal diseases of various types of hepatitis B (HB)and to study the relationship between them and hepatic diseases.Methods Stereological analysis was performed on 300 cases of liver tis- sues of various HBs and 10 cases of almost normal liver tissues.The sinusoidal figures were determined with the following parame- ters:hepatic sinusoidal number,total area,mean diameter.Results Compared with the control group,the above parameters of a- cute HB were all decreased (P<0.01);those of chronic HB-mild and chronic HB-middle didn't change (P>0.05);while in chron- ic HB-severe and chronic HB/LC groups,the hepatic sinusidal number decreased,total area,mean diameter all increased signifi- cantly (P<0.01),while the changes in chronic HB/LC were most significant.Conclusion Stereo[ogical analysis can provide the quantitative indexes and has important instructive significance to analyse correctly the intrahepatic microcirculation of patients with hepatic diseases.
关键词
乙型肝炎
肝窦病变
体视学分析
hepatitis B
hepatic sinusoidal diseases
stereological analysis
