摘要
目的探讨α-干扰素加胸腺肽对乙型肝炎病毒的疗效。方法 60例慢性乙型病毒性肝炎患者分为 HBV—DNA 低水平组[A 组,基因拷贝(1×10~2～9.9×10~3/μl)]及高水平组[B 组,基因考贝(1×10~4～10~8)/μl)]。在干扰素加胸腺肽治疗前、中、后采用荧光 PCR 法对两组患者作了血清HBV—DNA 定量测定,制定治疗方案。结果治疗前 HBV-DNA 转阴后再次出现 HBV—DNA 低水平复制[(基因考贝(1～5)×10~2/μl)]可作为病情复发的指标。疗程结束后 A、B 两组 HBV-DNA、HBeAg 转阴率分别为63%、70%和33%、43%。结论动态观察 HBV—DNA 含量的变化对制定治疗方案及预测病情复发有指导意义。
Objective To detect the relationship between serum HBV-DNA level and the therapeutic effect of interferon-α(IFN-α) and thymosin in the treatment of chronic hepatitis B.Methods Sixty cases of patients with chronic heaptitis B were divided into group A (serum HBV-DNA 1×10~2 copies/μl to 9.9×10~3 copies/μl) and gronp B (serum HBV-DNA 1×10~4to 1×10~8copies/μl). Fluorogenic quantitative PCR (FQ-PCR) Test was applied to detect the serum HBV-DNA amount in the two groups.Various IFN- α treatment plans were chosen according to serum HBV-DNA levels before,during and after the treatment.Results The treatment effcct on the cases with lower serum HBV-DNA level was better than that of the higher.During the treatment,those with guick decrease of serum HBV-DNA rosults better than those with slow decrease.Recurrence of lower serum HBV-DNA level (1 to5× 10~2 copies/μl)was racognized as indication of the recurrence of chronic hepatitis B.After treatment,serum clearance rate of HBV- DNA and HBeAg in group A was 63% and 70%,and 33% and 43% in group B..Conclusion Dynamic serum HBV-DNA level analysis would be helpful to determine antiviral treatment for chronic hepatitis B,It also indicates the recurrance of chronic hepatitis B.
