一种新型光学纯胡椒醛基氮杂环丙基羧酸酯的合成与表征

Synthesis and characterization of a new optically pure 3,4-methylenedioxyphenyl aziridino carboxylic acid ester

为发展新型手性配体,降低手性催化剂的合成成本,检验由芳醛与手性氨基酸酯缩合、还原反应的普适性,以L-丝氨酸为手性源,经酯化,缩合,还原氨化,关环等反应,设计合成了一种新的胡椒醛基氮杂环丙基羧酸酯5,其结构通过IR,1H NMR,13C NMR,HRMS进行了表征.发展了一条高效便捷合成这类具有光学活性化合物的方法.

For the development of new chiral ligands,reducing the cost of chiral catalysts and examining the universality of condensation and reduction of aromatic aldehydes with chiral amino acid ester,we designed and synthesized a new 3,4-methylenedioxyphenyl aziridino carboxylic acid ester from L-serine through esterification,condensation and reductive amination,which developed a highly efficient and convenient method for synthesis this kind of optically active compounds.The structure of aziridino carboxylic acid ester was confirmed by IR,1H NMR,13C NMR and HRMS.