氯沙坦对老年高血压病病人血压及血糖、胰岛素、脂蛋白水平影响

Effects of losartan on blood pressure,glucose, insulin, and lipoprotein in elderly hypertension

目的 探讨服用氯沙坦(Losartan)后的高血压病病人血糖、胰岛素、脂蛋白水平的变化。方法对26例高血压病病人服氯沙坦25～50 mg,每天1次,于用药前及治疗2个月后分别测定血糖、胰岛素、脂蛋白的血清浓度。结果 2个月后,病人收缩压、舒张压显著降低(P<0.01)。餐后血糖、餐后胰岛素水平及TC、TG、LDL、VLDL、apoB均显著降低(P<0.01,P<0.05),而HDL、apoA显著升高(P<0.05)。结论 氯沙坦降压效果确切,并可改变胰岛素抵抗和血脂水平,降低高血压病病人冠心病的危险性。

Objectire To explore the effects of losartan on the concentration of glucose,insulin and lipopro-tein in plasma in the patients with hypertension. Methods The concentrations of glucose insulin and lipoprotein were weasured both before and after receiving losartan for 2 months. Results The SBP and DBP decreased highly (P< 0.01); The concentrations of glucose and insulin in plasma and the TC TG LDL VLDL apoB were all in de-creased(P<0.01,P<0.05);The HDL,apoA creased significantly(P<0.01).Conclusion Losartan can improve insulin resistance and lipoprotein level and decrease the risk of coronary atherosclerosis heart disease in patients with hypertention.