13例妊娠合并Graves病的临床分析

Clinical analysis of pregnancy with Graves's disease

目的 分析Graves病治疗后妊娠时机及其母儿预后。方法 采用回顾性分析的方法,将13例妊娠前诊断为Graves病患者,按妊娠期间是否服用抗甲状腺药物分两组:甲组:妊娠期未服用抗甲状腺药物;乙组:妊娠期使用了抗甲状腺药物。对比研究其母儿合并症及并发症。结果 甲、乙两组妊娠前甲亢病程无差异,甲组停药至此次妊娠间隔明显短于乙组,乙组早产率,产后出血率及小于胎龄儿发生率明显高于甲组(P<0.05)。结论 Graves病在病情稳定后即可妊娠,妊娠后需严密监测母体及胎儿甲状腺功能;对于应用内基硫嘧啶治疗后需用甲状腺素片部分替代的孕妇.其胎儿甲状腺功能情况需严密监测。

Objective To study the proper time of pregnancy for patients suffered from Graves's disease and their maternal and fetal complications. Methods 13 cases of pregnancy women who had Graves's disease were classified into two groups: Group A: without and-thyroid therapy during pregnancy; Group B: with the treatment. The maternal and fetal complications were retrospectively compared. Results There was no difference in the duration of hyperthyriodism before gestadons in the two groups. The intenal between the stopping anti-thyroid treatment time to the time of pregnancy was significandy shorter in group A than group B. The maternal and fetal complications of group A were significantly lesser than group B ( P < 0.05) . Conclusions Whenever the general conditions of the patients who were diagnosed of Graves's disease are stabilized,they can be pregnant. Their maternal and fetal thyroid function should be monitored closely,especially for those mothers who had hvpothyroidism caused by the therapy of propylth-iouraril during pregnancy and with the replacement of thyroxine.