白细胞介素-2及肿瘤坏死因子-α在正常分娩中的作用

The roie of interieukin-2 and tumor necrosis factor-alpha in normal labor and the stage of labor

目的 探讨细胞因子白细胞介素-2(IL-2)及肿瘤坏死因子-α(TNT-α)在分娩发动、产程中的变化及与前列腺素E_2(PGE_2)的关系。方法 采用放射免疫分析法测定正常妊娠晚期(孕28～32周)、妊娠足月未临产、足月自然临产及产程中孕妇静脉血中PGE_2、TN-α、IL-2水平的变化。结果 足月妊娠未临产与正常妊娠晚期相比,孕妇血中PGE_2、IL-2水平无明显变化,临产后PGE_2、IL-2水平明显升高,随产程进展呈进行性升高,IL-2升高与PGE_2呈正相关。TNF-α在妊娠晚期、临产前后及各产程中均无明显变化。结论 细胞因子IL-2参与分娩的发动及促进产程的进展,TNF-α在正常分娩的发动及产程中作用不明显。

Objective To study the role of cytokines interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-a) in the onset of normal labor and the role in different stages of labor,as well as their relationship with Prostaglandin E2 (PGB2) . Methods The IL-2,TNF-a and PGE2 levels of maternal plasma were measured by a radioimmunoassay in later half pregnancy,term pregnancy and the difference stages of labor in term pregnancy respectively. Results The maternal plasma IL-2 and PGF2 levels in term pregnancy were the same as those of normal 28 to 32 weeks of pregnancy,but were raised gradually with the progress of labor. There was no significant difference of TNF-a levels in 28 to 32 weeks of pregnancy,term pregnancy and various stages of labor. Conclusions IL-2 plays a role in the onset and progress of normal labor,however,TNF-a has no relationship with the onset and progress of normal labor .