43例子宫内膜癌血清SA、CP_2、CA_(125)的研究

The study at sen SA, CP_2 and CA_(125) in patients with endometrial carcinoma (43 cases)

目的 评价血清SA、CP_2、CA_(125)在子宫内膜癌诊断及判断预后中的意义。方法 测定43例子宫内膜癌病人和30例对照正常女性静脉血清SA、CP_2、CA_(125)值,并分析其与疾病分期、细胞分化、瘤组织侵肌、腹水癌细胞阳性和淋巴结转移等预后因素之间的关系。结果 在子宫内膜癌病人中,SA灵敏度和特异度分别为24/43(55.81％)、26/30(86.67％);CP_2为22/43(51.16％)、29/30(96.67％);CA_(125)为9/43(20.93％)、30/30(100％)。CP_2升高程度与瘤组织侵肌正相关;CA_(125)升高程度与瘤细胞分化、病人分期正相关。联合3项指标检测,灵敏度和特异度可达81.39％、83.33％。结论 SA、CP_2单项检测子宫内膜癌灵敏度高于CA_(125);并且CP_2与CA_(125)升高程度将影响病人的预后;联合多项指标检测有可能优于单项。

Objective To evaluate the significance of sera SA,CP2,and CA12s for diagnosis and prognosis of endometrial carcinoma. Methods The values of sera concentrations of SA,CP2,and CA125 of 43 patients with endometrial carcinoma and 30 normal women were measured respectively. The related prognostic factors were studied,such as FIGO staging,cell differentiation,myometrial invasion,ascitic cancer cells positive or lymph nodes invasions. Results In endometrial carcinoma,the sensitivity and specificity of sera SA were 24/43 (55.81%),26/30 (86.67%); CP2 were 22/43 (51.16%),29/30 (96.67%); and CA125 were 9/43 (20.93%),30/30 (100%) respectively. The increase of sera CP2 was found more frequently in patients with deep myometrial invasion,while sera CA125 was found to be higher in patients with poorly differentiated tumors or late stage. In combinadon test of SA,CP2 and CA125,the sensitivity and specificity were 81.39 % 83.33%. Condusoos Either sera SA or CP2,the sensitivity is higher than CA125. However,CP2 and CA125 can be used as prognostic factors for patients with endometrial carcinoma. Combination test may be better than single test.