子宫内膜癌肿瘤家族聚集性研究

The study of familial aggregation of endometrial carcinoma

目的 通过家系调查探讨子宫内膜癌家族聚集情况。方法 采用回顾性分析方法,对1982年7月～1999年7月间住院的193例子宫内膜癌患者及其亲属进行调查,登记家族中子宫内膜癌、乳腺癌、非息肉性结直肠癌、卵巢癌等恶性肿瘤,并经病理证实。结果 具有阳性肿瘤家族史者46例(23.9％),其中非特异性肿瘤聚集组36例(18.2％),平均年龄59.0岁,病理类型以腺癌为主;家族性肿瘤聚集组8例(4.7％),平均年龄53.7岁,遗传性癌组2例(1％),平均年龄为52.1岁;无肿瘤家族史家族性子宫内膜癌147例(76.1％),平均年龄57.6岁。结论对属于家族性子宫内膜癌的妇女应及早定期随访和监测,并对高危人群的发病及早作出诊断并采取治疗措施。

Objective To study the pedigree of familial aggregation of endometrial carcinoma.Methods Endometrial carcinoma patients and their relatives were inquired to complete the registration of endometrial carcinoma and all kinds of other cancers especially breast carcinoma, non - polypoid colorectal cancer and ovarian carcinoma , which were proved pathologically. Results From July 1982 to July 1999, 46 out of 193 patients admitted in our hospital were found with positive familial tumor history, of which non- specific cancer aggregates were found in 36,the mean age of onset was 59.0; familial cancer aggregation were found in 8 with mean age of onset as 53.7, while the mean age of 2 heriditary cancer was 52.1 years. Conclusion Putative high - risk women with familial endometrial carcinoma history should have periodical check - up so as to make early diagnosis and treatment.