短程三联疗法治疗幽门螺杆菌相关性十二指肠球部溃疡疗效观察

One-Week Use for the Treatment Of Helicobacter Pylori-related Duodenal Ulcer

目的 为了探讨奥美拉唑、克拉霉素、阿莫西林短程三联疗法治疗幽门螺杆菌(Hp)相关性十二指肠球部溃疡(DU)的疗效。方法 将79例符合条件的患者随机分为两组,其中A组(40例),口服克拉霉素500mg,阿莫西林1000mg,每日2次,奥美拉唑20mg,每日1次治疗1周。B组(39例),口服甲硝唑400mg,阿莫西林1000mg,每日2次,奥美拉唑20mg,每日1次。两组疗程均为1周,1周后继续口服奥美拉唑20mg,每日1次治疗1周,停用奥美拉唑1个月后复查胃镜。结果 A组Hp根除率为92.5％,明显高于B组的Hp根除率76.9％,有显著性差异(P<0.05)。而对Du的愈合率A、B两组分别为95.0％、89.7％,两者无明显性差异P>0.05)。结论 奥美拉唑、克拉霉素、阿莫西林三联短程疗法是治疗Hp相关性DU理想的方案。

Objective To study eradication of the triple therapy with omeprazole,clarithomycin (Cla) plus amoxycillin in Helicobacter pylori(Hp)-related duodenal ulcer(DU). Methods 79 patients with HP-related duodenal ulcer were randomly divided into 2 groups. Group A (n = 40) was treated with triple therapy of omeprazole 20mg qd,Cla500mg bid and amoxycillin lOOOmg bid for 1 week. Group B (n = 39) was treated with omeprazole 20mg qd,amoxycillin 100mg bid and metronidazole 400mg bid for 1 week. And two groups were treated with omeprazole 20mg qd for 1 week. The Hp status was determined by rapid ureas test and histology of Giemsia staim after four weeks. Results The eradication rates of Group A. Group B were 92. 5%,76.9% respectively. The difference of eradication rate between Group A and Group B was statistically significant (P<0. 05).The gealing rates of DU were 95. 0% in Group A and 89. 7% in Group B (P>0. 05). Conclusions Our results show that the one-week use of omeprazole,Cla and amoxycillin for the treatment of Hp-related Du is the optimal regimens.