呋喃唑酮、法莫替丁、乐得胃联合治疗十二指肠溃疡临床观察

Clinical Study of Two Weeks Furazolidone Combination Therapy for the Treatment of Duodenal Ulcer

目的:探求适用于低收入人群十二指肠溃疡(DU)患者经济、有效的治疗方案。方法:将156例活动性DU患者随机分成2组,治疗组82例,用呋喃唑酮200mg、乐得胃2片每天三次,法莫替丁20mg早晚各一次治疗2周:对照组74例,用羟氨苄青霉素500mg、胶体果胶铋100mg(以Bi计)每天三次,奥美拉唑40mg每天早晨一次治疗2周,疗程结束时复查胃镜观察溃疡愈合情况,疗程结束后4周取胃粘膜检查幽门螺杆菌(HP),观察HP根除情况。结果:治疗组和对照组对DU有效率分别为93.6％和94.5％,无统计学差异(P】0.05),HP根除率分别为82.3％和95.7％,对照组明显高于治疗组(P【0.01);治疗组2例出现白细胞轻度降低(3.5×10~9/L),对照组1例ALT轻度升高,治疗结束后均恢复,余无严重不良反应。呋喃唑酮、乐得胃、法莫替丁联合治疗DU,虽然HP根除率稍低,但经济、安全、有效,尤其适用于低收入患者。

Objectives: An econonmic and effective therapy in DU for low - income pa-tients was studied. Methods: 156 patients with active DU were randomised into two groups.Group A received furazolidone 200mg, L. D. W. tablets 2 #, each thrice daily, combined withfamotidine 20mg each twice daily; Group B receivde amoxicillin 500mg, colloidal Bismuth pectin100mg (the content of Bismuth) each thrice daily, combined with omeprazole 40mg each oncedaily. Two groups were administered for two weedks. Four weeks later, the stamoch mucose ofall patients were examed in order to show the eradication rates of HP. Results: (1) Ulcer effec-tive rates were 93.6% and 94.5% in group B. (P>0.05); (2)Eradication rates of HP were 83.2% and 97.5% in group A and group B. Group B was sig-nificantly higher than group A (p<0.01): (3)The side effect: Two patients in group A werelittle lower with WBC(3.5×10°/L), Conclusions: Furazolidone combined with L. D. W. tabletsand famotidine was highly effective、safe and economical in the cure of duodnal ulcer. It was fit-ted for low - income patients.