期刊文献+

抗癌药鬼臼毒素衍生物的量子化学研究

Quantum Chemicl Study of Podophyllotoxin Derivatives as Potential Antitumor Drugs
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摘要 对去甲表鬼臼毒素23个衍生物进行了量子化学计算,结合它们对抑制L_(1210)白血病细胞生长的活性,发现这些化合物的E环是重要的活性部位,是供电子的主要部位,能与受体正电部位结合,其负电性越高,活性越强,文章对C4位为有效的修饰位点进行了量子化学方面的探索。 A series of podophyllotoxin derivatives were analyzed by AM1 method. Some information given according to the calculation results and the inhibition of L_(1210) indicated that the E ring is the main center of negative electricity, the main center of positive electricity is changed by the structure of different substitution, the results show that the hole of negative charge in molecule easily combines with an acceptor within the molecule.
出处 《中山大学研究生学刊(自然科学与医学版)》 1999年第4期64-69,共6页 Journal of the Graduates Sun YAT-SEN University(Natural Sciences.Medicine)
关键词 鬼臼毒素 电子结构 抗肿瘤活性 AM1 Podophyllotoxin derivatives Antitumor activities Election Structure AM1
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  • 1王志光,张椿年,马维勇.鬼臼毒素的化学和抗肿瘤活性研究[J]中国医药工业杂志,1991(12).
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