洛赛克、羟氨苄青霉素合并硫糖铝三联疗法对根除幽门螺杆菌的研究

Tripletherapy with losec,amoxicillin andsucralfateforeradication of Helicobacter pyloriin duodenalulcer disease

目的 探讨洛赛克、羟氨苄青霉素合并硫糖铝三联疗法对根除幽门螺杆菌（Ｈｐ） 的疗效。方法 将８３ 例Ｈｐ 阳性十二指肠溃疡患者随机分为２ 组。Ａ 组４２ 例，以洛赛克２０ｍｇ、每日２ 次，羟氨苄青霉素５００ｍｇ、每日４ 次和硫糖铝１０００ｍｇ、每日４ 次，治疗２ 周：Ｂ组４１ 例，以洛赛克２０ｍｇ、每日２ 次和羟氨苄青霉素５００ｍｇ、每日４ 次，治疗２ 周作为对照组。在治疗前和疗程结束４ 周以上，用快速尿素酶试验和组织学改良Ｇｉｅｍｓａ 染色法检查Ｈｐ。结果 Ａ 组的Ｈｐ 根除率为９２．９％ ，明显高于Ｂ 组的７０．７％ （Ｐ＜０ ．０１）。Ａ、Ｂ两组副反应小，均能耐受。结论 洛赛克、羟氨苄青霉素合并硫糖铝三联疗法的Ｈｐ 根除率高、安全，耐受性好，所用的硫糖铝副反应小，价廉。可作为洛赛克加羟氨苄青霉素二联疗法的补充，是一种新的较为理想的Ｈｐ 根除方案。

Objective To evaluate a new tripletherapy with Losec 20mg bid plusamoxicillin 500mg qid and sucralfate 1000mg qid for two weeks (group A) versus double therapy with Losec 20mg bid plus amoxicillin 500mg qidfortwo weeks(group B). Methods 83 patients with duodenal ulcerand helicobacter pylori(Hp)infection were randomly dividedinto 2 groups. Group A(n= 42) treated with triple therapy for two weeks.Group B(n= 41) treated with doubletherapy fortwo weeks.The Hp status was determined by rapid ureasetestand historyof Giemsa Stain beforeandfour weeksaftercompletion oftherapy.Results The eradication rate of group A(92.9 %)wassignificantly higherthan that of group B(70 .7% ),( P< 0 .01) . Side effects were minor. Conclusions Two week triple therapy with Losec. Amoxicillin and Sucralfate is highly effective,safeand well toleratedtreatmentforeradication of Hpinfection and may be an alternativeto Losec amoxicillin doubletherapy.