奥美拉唑在急性重型颅脑损伤中的应用——附160例临床分析

Application oflosecin severe acute head injury - 160 cases

目的 应用奥美拉唑（ 洛赛克）预防及治疗急性重型颅脑损伤患者上消化道病变１６０ 例。方法 奥美拉唑４０ｍｇ 静脉注射每日１ 次。分为两组观测：第１ 组４０ 例，用胃镜监测治疗效果。第２ 组１２０ 例，并有回顾性病例为对照组，用胃管抽取胃液监测治疗效果。结果 第１ 组４０ 例，治疗７ 天后，治愈率达７５ ．８ ％ 。治疗１４ 天后，治愈率达９３．９％ 。第２ 组１２０ 例，治疗第２、３ 周胃液潜血转阴率分别为７８％ 和９８ ％ 。而对照组分别为４５％ 和６８ ．６％ 。两组比较差异有非常显著性（Ｐ＜ ０ ．００１）。结论 奥美拉唑是一种新型的胃酸泵抑制剂，它可以抑制胃酸分泌的最后步骤，使胃酸分泌减少，使胃液ｐＨ 值上升。保护了胃粘膜组织。使之虽处于应激状态，不再受损害，并使已经受损的胃粘膜得以修复。

Objective Losec wasused andtranttheupper GItractblecdingin 160 patients withsevere acute headinjury.Methods Losec (40mg/d) .thepatients was dividedintotwo groups:(1) Thefirstgroup contained 40 patients usingfibergastroscopyfor monitoring.(2) Thesecond group 120 casesretrospectivecas esserved ascontrolsand were monitored by occultblood examination of gastricjuice.Results (1) Of40 pa tientin thefirstgroupincludingthecurativerates were75.8 % and 93 .9% at7 and14 daysaftertreatment. (2) In thesecond grouptheratesof negativeescultblood were 78 % and 98% at 2 and 3 weeks aftertreat ment,butthose ofthecontrol were 45% and 68.6 % (P< 0.01).Conclusions Losecis a new gastric acid pumpinhibitor,which canreducethe gastricacid secretion andrepairthe damaged gastric macosa.