麻醉诱导时乳化依托咪酯和异丙酚对呼吸循环的影响

The Effects of Emulsive Etomidate and Propofol on Respiratory and Circulatory Function During Induction of Cardiac Surgery

目的评价乳化依托咪酯、异丙酚对呼吸、循环的影响。方法60例心脏瓣膜置换术病人按不同给药分为Ⅰ组（异丙酚1．5mg／kg），Ⅱ组（异丙酚2．0mg／kg），Ⅲ组（乳化依托咪酷0．3mg／kg）。应用温度稀释法测定血流动力学指标，同时观察呼吸功能。站票1．Ⅱ组呼吸暂停发生率98％，Ⅰ组为50％，Ⅲ组为0；2异丙酚组：MAP、SVR、CI下降幅度明显大于乳化依托咪酯组。结论心脏手术病人麻醉诱导时，乳化依托咪酯组较异丙酚更为安全。

Objective To evaluate the effect of emulsive etomidate and propofol onrespiratory and circulatory function. Methods 60 patients undergoing cardiac valvereplacement were divided into three groups:i.e., group I (propofol 1.5mg/kg), groupII(propofol 2.0mg/kg), and group III(emulsive etomidate 0.3mg/kg). Hemodynamics indiceswere monitored by the thermodilution method and respiratory function observa-tion- ResuIts (1) The incidence of asphyxia was 98% in group 11, 50% in group I and 0 ingroup III; (2) In propofol group, MAP, SVR and CI decreased markedly than those ofemulsive etomidate group. ConCIIIbon Etomidate is safer than propofol during induction ofanesthesia in patients undergoing open heart surgery.