一次肠道传播性病毒性肝炎流行后的随访调查

Follow-up of an epidemic of enterically transmitted viral hepatitis

目的武汉某校发生过一次肠道传播型肝炎流行，从粪便中检出与TT病毒同源的病毒，随访调查以了解这一新型病毒的感染过程。方法急性期和随访血清检测ALT和病毒片段。结果急性期、发病后6个月和18个月ALT增高分别为100％，29．6％和13．9％；检出病毒片段分别有77．0％，685％和18．5％。18个月时ALT正常者病毒血症也消失的80．6％；ALT增高的15例病人仅2例（133％）检出病毒，可能因此时病毒水平多低于可检出水平。结论这一病毒可长期血液携带，其血液传播的重要性，远非甲型肝炎和成型肝炎病毒所可比拟。

An outbreak of enterically transmitted hepatitis occurred at a technician school in Wuhan during 1996. The viral fragments with nucleotide homology of trans fusion transmitted virus (TTV) were detheted in patient feces. Follow-up investigstions were carried out to elucidate the infection course of this novel virus. Methods Sera were collected to test alanine transaminase (ALT) and the virus. Results During the acute phase, and at 6 and 18 months after onset, ALT elevation was in 100%, 29.6% and 13.9% of patients, and viral fragments were detected in 77.0%, 68.5% and 18.5%, respectively. Among the sera followed up at 18 months, the viremia was lost with normal ALT in 80.6% of patients. On the other hand, the virus DNA was only detected in 2 (13.3%) of 15 sera with elevated ALT, which might be explained as undetected level for most patients at this time. Conclusion The viremia may be prologs and its blood transmission may be much more imPOrtant than that of hepatitis A virus and hepatitis E virus.[