脑型疟灵长动物模型及其病理机制的探讨

The Primate Models of Cerebral Malaria and It's Pathology

通过换人血的方法使恶性疟原虫（ Ｐｌａｓｍｏｄｉｕｍ ｆａｌｃｉｐａｒｕｍ） 在熊猴（ Ｍａｃａｃａ ａｓｓａｍｅｎｓｉｓ） 和猕猴（ Ｍｍｕｌａｔｔａ） 体内大量繁殖， 原虫密度特高的２ 只熊猴因内脏器官大出血而死亡．介绍脑型疟灵长动物模型及其病理机制．

The present paper reports Plasmodium falciparum in the harm intestinal organs of Macaca assamensis .We observed the developments and multiplications of P falciparum in two species of the old World monkey including M mulatta and M assamensis ,a part of the monkey's blood be drawn off and a same amount of human blood be transfused into it so that there will be abundant human red blood cells in which the parasites inoculated may multiply.It is very intersting to note that in the monkeys( M mulatta and M assamensis ) the blood of which has been partly or largly replaced by human blood, P falciparum did flourish with the highest infection of 46% of the red blood cells.2 M assamensis of infection rates 26% and 46% died of serious intestinal haemorrhages very much like local pernicious human cerebral malaria.We find the present achievement quite useful in that it provides us with a new method to study the cerebral malaria.Besides,such animals may also serve sonewhat as models for the study of infectious hepatitis,reproductive physiology.