补骨脂素和异补骨脂素在兔体内脏的分布滞留研究

Distribution and Remainer of Psoralen and Isopsoralen in Rabbit Viscera

补骨脂素和异补骨脂素是中药补骨脂的主要活性成分． 本文为了研究药物在脏器中的分布滞留问题， 为临床安全用药提供理论依据， 首先给家兔口服补骨脂水煎液， ２４ｈ 后， 以溴代十六烷基三甲胺（ 简称ＣＴＭＡＢ） 为胶束试剂， β－ 环糊精（ 简称β－ ＣＤ） 为包含试剂的荧光法， 对主要脏器心、肝、肾、肺、胃、卵巢、睾丸中所含的补骨脂素和异补骨脂素进行测定． ３ 次测定结果相近， 效果良好．

Psoralen and isopsoralen are the principle active components in the fruits of Psoralea corylifolia L.In order to study the distribution and remainder of the drug in viscera,and provide scientific basis for clinical practice,let the rabbits take the aqueous decoction solution of Psoralea corylifolia L.First,after 24 hours,psoralen and isopsoralen in heart,liver,kidney,lung,stomach,ovary and testis were determined by fluorescent method with CTMAB as micellar reagent,β-CD as inclusion reagent.The three results were close and satisfied.