膀胱移行细胞癌中P_(53)、nm23-H_1蛋白表达的意义

The Expression of P_(53) ,nm23-H_1 Protein and Its Significance in Bladder Transitional Cell Carcinoma

目的 :探讨 P53及 nm2 3- H1蛋白在膀胱移行细胞癌的表达及与预后的关系 :方法 :应用免疫组织化学 S- P法 ,用 P53、nm2 3- H1单抗对 68例膀胱移行细胞癌进行研究。结果 :P53蛋白阳性表达 2 3例 ( 34.3% ) ,其阳性表达与肿瘤的病理组织学分型、复发、3年生存期有关 ( P<0 .0 5 )。nm2 3- H1蛋白阳性表达 41例 ( 60 .4% ) ,其阳性表达与肿瘤的复发、浸润及转移呈负相关 ( P<0 .0 5 )。结论 :P53、nm2 3- H1可作为判断膀胱移行细胞癌恶性程度、复发、浸润及转移的指标。

Purpose:To investigate the expression of P 53 ,nm23 H 1 protein in bladder transitional cell carcinoma and its relatiouship to the prognosis of the trmor.Methods:Immunohistochemical S P method was used to studing the immunoreactivity of P 53 , and nm23 H 1 monocolonal antibody in 68 case of bladder transitional cell carcinoma.results:The P 53 protein positive was 23 cases (34.3%) and concerned with pathological type ,recurrence ,the 3 year survival rate of the tumor ( P <0.05).nm23 H 1 protein positive was 41 cases (60.4%) and negative concerned with recurrence,invasiveness and metastasis of the tumor ( P <0.05).