摘要
Objective To determine whether the antiatherogenic effect of L arginin e is due to an inhibition of vascular cell adhesion molecule 1 (VCAM 1) expres sion in the aortae of hypercholesterolemic rats. Methods Twenty four male Wistar rats were randomized into three gr oups : Group NC with normal diet (NC, n=8), Group CC with 4% cholesterol and 1% choli c acid diet (CC, n=8), Group AC with 4% cholesterol and 1% cholic acid diet supp lemented with 3% L arginine HCl in the drinking water (AC, n=8). Eight weeks la ter, the blood samples were collected for biochemical studies, and the aortae we re harvested for RT PCR and immunohistochemical studies.Results The results showed that dietary L arginine supplementation red uced expression of VCAM 1 in protein level and mRNA level. Conclusion Inhibitory effect of dietary supplementation of L argin ine on VCAM 1 expression may be one of the mechanisms of its antiatherosclerosis.
Objective To determine whether the antiatherogenic effect of L arginin e is due to an inhibition of vascular cell adhesion molecule 1 (VCAM 1) expres sion in the aortae of hypercholesterolemic rats. Methods Twenty four male Wistar rats were randomized into three gr oups : Group NC with normal diet (NC, n=8), Group CC with 4% cholesterol and 1% choli c acid diet (CC, n=8), Group AC with 4% cholesterol and 1% cholic acid diet supp lemented with 3% L arginine HCl in the drinking water (AC, n=8). Eight weeks la ter, the blood samples were collected for biochemical studies, and the aortae we re harvested for RT PCR and immunohistochemical studies.Results The results showed that dietary L arginine supplementation red uced expression of VCAM 1 in protein level and mRNA level. Conclusion Inhibitory effect of dietary supplementation of L argin ine on VCAM 1 expression may be one of the mechanisms of its antiatherosclerosis.
