摘要
Objective To investigate the role of dobutamine stree echocardiography in evaluating cardiac betaadrenergic receptor (AR) function and responsive ness in children Methods Left ventricular ejection fraction (EF), fractional shortening (FS), left ventricular end systolic volume index (ESVI), the ratio of systolic b lood pressure and ESVI (SP/ESVI) were measured by dobutamine stress echocardiogr aphy (DSE) in 30 children with AR hypersensitivity, 15 children with dilated cardiomyopathy and 30 normal children respectively Results Before pharmacological stress, EF and FS were 072 and 039 r es pectively in AR hypersensitivity group versus 070 and 035 respectively i n control group There was no difference of the indices between the two groups ( P >005) SP/ESVI was 076, higher than the value of 066 in co ntro l group ( P <005); EF, FS and SP/ESVI were 041, 015 and 01 0 re spectively, which were significantly lower than those in control group After d o butamine stress of 5?gkg-1min-1 and 10?gkg-1min -1, EF, FS and SP/ESVI were sig nificantly increased in patients with AR hypersensitivity and there were no changes in children with dilated cardiomyopathy compared with values of baseline Conclusion Cardiac AR function and responsiveness can be evaluated by dobutamine stress echocardiography
Objective To investigate the role of dobutamine stree echocardiography in evaluating cardiac betaadrenergic receptor (AR) function and responsive ness in children Methods Left ventricular ejection fraction (EF), fractional shortening (FS), left ventricular end systolic volume index (ESVI), the ratio of systolic b lood pressure and ESVI (SP/ESVI) were measured by dobutamine stress echocardiogr aphy (DSE) in 30 children with AR hypersensitivity, 15 children with dilated cardiomyopathy and 30 normal children respectively Results Before pharmacological stress, EF and FS were 072 and 039 r es pectively in AR hypersensitivity group versus 070 and 035 respectively i n control group There was no difference of the indices between the two groups ( P >005) SP/ESVI was 076, higher than the value of 066 in co ntro l group ( P <005); EF, FS and SP/ESVI were 041, 015 and 01 0 re spectively, which were significantly lower than those in control group After d o butamine stress of 5?gkg-1min-1 and 10?gkg-1min -1, EF, FS and SP/ESVI were sig nificantly increased in patients with AR hypersensitivity and there were no changes in children with dilated cardiomyopathy compared with values of baseline Conclusion Cardiac AR function and responsiveness can be evaluated by dobutamine stress echocardiography
