摘要
Objective To investigate the variations of electroencephalogram (EEG) and brain evoked potentials (BEPs) to explore their clinical value in diagnosing Al zheimer's disease (AD) and senile schizophrenia (SS) Methods Thirtynine patients with AD according to DSMR (Diagnostic and Statistical Manual of Mental Disorders, rev), 34 patients with SS and 40 normal aged subjects were included in this study The BEAMEEG (brain elect rical activity mapping), auditory evoked potentials (AEP), visual evoked potent ials (VEP), auditory brainstem response (ABR) and cognitive P300 were recorded f rom the scalps of all subjects with a Dantec Concerto SEEG16 Instrument Results The abnormal ratio of EEG was significantly higher in AD patients (875%, P<005) than in normal controls (282%) and schizophrenic patien ts (667%) In AD and SS group, a lowdensity band was seen in BEAMEEG Bo th and power at all recording sites were increased significantly in AD gro up than in normal controls (P<005); the and power were increased at major recording sites in SS group In AD group, the power of band was decreased at the posttemporal, anteriortemporal and vertical areas (P<0 05); the same va riation presented at the frontal and vertical areas in SS group (P<005 or P<00 1) The power of band of AD patients was increased at the frontal and post t emporal areas (P<005 or P<001); the same increasing appeared at the frontal, m idtemporal and occipital areas in SS patients (P<005) Significantly pr olonge d latencies were found with the major components of both AEP and VEP of AD patie nts Schizophrenic patients presented reduced P2 latency of VEP The amplitud es of major components of AEP, VEP and P300 were decreased in SS patients, and wer e further decreased in AD patients AD patients presented more abnormal ABR tha n SS patients All the variations of BEPs had statistical significance (P<0 05 or P<001) The abovementioned variations in SS group were compared with t he cor responding data of 46 general schizophrenics (one of our earlier studies), and n o significant differences were found The electrophysiological variations of SS patients seemed to be related to the suffering of the disease Conclusion The variations of EEG, BEAM and BEPs among AD patients, schizo phrenic patients and normal controls are confirmed The diagnostic value of BEA MEEG and BEPs is discussed
Objective To investigate the variations of electroencephalogram (EEG) and brain evoked potentials (BEPs) to explore their clinical value in diagnosing Al zheimer's disease (AD) and senile schizophrenia (SS) Methods Thirtynine patients with AD according to DSMR (Diagnostic and Statistical Manual of Mental Disorders, rev), 34 patients with SS and 40 normal aged subjects were included in this study The BEAMEEG (brain elect rical activity mapping), auditory evoked potentials (AEP), visual evoked potent ials (VEP), auditory brainstem response (ABR) and cognitive P300 were recorded f rom the scalps of all subjects with a Dantec Concerto SEEG16 Instrument Results The abnormal ratio of EEG was significantly higher in AD patients (875%, P<005) than in normal controls (282%) and schizophrenic patien ts (667%) In AD and SS group, a lowdensity band was seen in BEAMEEG Bo th and power at all recording sites were increased significantly in AD gro up than in normal controls (P<005); the and power were increased at major recording sites in SS group In AD group, the power of band was decreased at the posttemporal, anteriortemporal and vertical areas (P<0 05); the same va riation presented at the frontal and vertical areas in SS group (P<005 or P<00 1) The power of band of AD patients was increased at the frontal and post t emporal areas (P<005 or P<001); the same increasing appeared at the frontal, m idtemporal and occipital areas in SS patients (P<005) Significantly pr olonge d latencies were found with the major components of both AEP and VEP of AD patie nts Schizophrenic patients presented reduced P2 latency of VEP The amplitud es of major components of AEP, VEP and P300 were decreased in SS patients, and wer e further decreased in AD patients AD patients presented more abnormal ABR tha n SS patients All the variations of BEPs had statistical significance (P<0 05 or P<001) The abovementioned variations in SS group were compared with t he cor responding data of 46 general schizophrenics (one of our earlier studies), and n o significant differences were found The electrophysiological variations of SS patients seemed to be related to the suffering of the disease Conclusion The variations of EEG, BEAM and BEPs among AD patients, schizo phrenic patients and normal controls are confirmed The diagnostic value of BEA MEEG and BEPs is discussed
