丝裂霉素C术中应用预防翼状胬肉复发的前瞻性研究

Prospective study of preventing pterygium recurrence by topical intraoperative mitomycin C

目的 前瞻性研究术中应用丝裂霉素Ｃ降低翼状胬肉术后复发的效果；方法 将７８ 眼单纯翼状胬肉患者随机分为两组，单纯切除法切除胬肉后，其中一组在术中一次性应用０ ．２ｇ·Ｌ－１ 的丝裂霉素Ｃ于球结膜和巩膜之间，５ｍｉｎ 后冲去；结果 平均随访２５ｍｏ，用药组胬肉的复发率为５ ．２％ ，未用药组复发率为３２ ．４％ ；结论 术中应用丝裂霉素Ｃ能够达到降低胬肉复发的目的，同时也避免了严重并发症的发生。

Objective To evaluate the effect of single application mitomycin C to prevent recurrence in primary pterygium surgery.Methods seventy-eight pterygium were divided into two groups,simple excise pterygium and apply 0.2g·L -1 mitomycin C between the conjunctiva and sclera.Push mitomycin C away with sodium solution after 5 minutes in one groups.Results Following 25 months,5.2% recurrent rate was in mitomycin C group,and 32.4% in controlled group.Conclusions Topical mitomycin C in operation will decrease pterygium recurrence,and no serious complication happen.