白细胞在颅脑损伤后继发性损伤中的作用

The role of the leukocytes in pathogenesis of secondary brain injury

４０例急性颅脑损伤患者，伤后４８ｈ内检测外周血中白细胞粘附性、吞噬后释放Ｏ－２·的水平，ＭＤＡ，白细胞计数和中性粒细胞数。结果表明：急性颅脑损伤患者上述各指标均显著高于对照组（Ｐ＜０．０５），且与脑损伤的严重程度呈正相关（Ｐ＜０．０５）。

The levels of leukocyte count, neutrophil number, leukocyte adhesiveness, leukocyte releasing oxygen free radical (O - 2· ) after phagocytosing bacteria and serum lipid peroxide MDA were determined in the peripheral blood of 40 patients with acute head injury within 48 hours and 22 normal adults. These levels of patients were significantly higher than those of the controls ( P <0.05), and increased with the severity of craniocerebral injury elevation. The leukocyte count and neutrophil number of those patients who died were significantly higher than these of those survived patients ( P <0.05). It suggested that leukocytes aggravated the secondary brain injury after crainocerebral injury by increasing of leukocyte adhesiveness, and generating and releasing oxygen free radical, and measurement of leukocyte count and neutrophil number in the peripheral blood could evaluate the prognosis of the patient with craniocerebral injury.