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Studies on the Interaction of DNA and Ru(1,10-phenanthroline)_2-(dipyrido[3,2-a:2′,3′-c]phenazine)^(2+)

Studies on the Interaction of DNA and Ru(1,10-phenanthroline)_2-(dipyrido[3,2-a:2′,3′-c]phenazine)^(2+)
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摘要 The interaction of Ru(phen) 2(dppz) 2+ (phen=1,10 phenanthroline,dppz=dipyrido[3,2 a:2′,3′ c]phenazine) and the calfthymus DNA were studied with fluorescence and ultraviolet visible absorption spectroscopy. The ultraviolet visible absorption spectrum of Ru(phen) 2(dppz) 2+ , calfthymus DNA, and their interaction demonstrated that Ru(phen) 2(dppz) 2+ intercalated into the double helix of DNA via the ligand dppz. Fe(CN) 6 4- and NaCl can not quench the fluorescence of Ru(phen) 2(dppz) 2+ DNA, which was in agreement with the intercalation mode. The interaction of Ru(phen) 2(dppz) 2+ (phen=1,10 phenanthroline,dppz=dipyrido[3,2 a:2′,3′ c]phenazine) and the calfthymus DNA were studied with fluorescence and ultraviolet visible absorption spectroscopy. The ultraviolet visible absorption spectrum of Ru(phen) 2(dppz) 2+ , calfthymus DNA, and their interaction demonstrated that Ru(phen) 2(dppz) 2+ intercalated into the double helix of DNA via the ligand dppz. Fe(CN) 6 4- and NaCl can not quench the fluorescence of Ru(phen) 2(dppz) 2+ DNA, which was in agreement with the intercalation mode.
作者 LING Lian sheng, HE Zhi ke,ZHANG Ping yi,ZENG Yun e College of Chemistry and Enviromental Science, Wuhan University, Wuhan, 430072,China
出处 《Wuhan University Journal of Natural Sciences》 CAS 1999年第4期482-486,共5页 武汉大学学报（自然科学英文版）
关键词 Ru(phen) 2(dppz) 2+ DNA absorption spectroscopy fluorescence intercalate binding Ru(phen) 2(dppz) 2+ DNA absorption spectroscopy fluorescence intercalate binding
分类号 Q523 [生物学—生物化学]
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参考文献16

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Wuhan University Journal of Natural Sciences
1999年 第4期

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