摘要
目的：探讨胃蛋白酶在胃部疾病中的作用。方法：采用ＨＲＰ标记ｊａｃａｌｉｎ，通过ＥＬＩＳＡ法检测各种胃病患者胃液中的胃蛋白酶。结果：胃蛋白酶在正常组（１５例）、胃炎组（３０例）、十二指肠溃疡组（３０例）、胃溃疡组（３０例）及胃癌组（１０例）中含量无显著性差异，但胃液ｐＨ＜３的胃蛋白酶含量明显高于ｐＨ＞４的酶含量，表明胃酸增加，胃蛋白酶的分泌亦增加，但胃蛋白酶与胃部疾病的发生关系不密切。结论：胃粘膜屏障的局部缺陷使之对胃蛋白酶抵抗力下降，可能与消化性溃疡的发生关系更为密切。
Objective: To study the effects of Gastrie Juice pepsin on gastric disease. Methods: The pepsin contents of gastric juice were determined by JacalinHRP ELISA assay.Result:There were no significant differences in the pepsin contents among the normal controls and patients with various gastric diseases including gastritis,duodenal ulcer,peptic ulcer and carcinoma of stomach.But the pepsin contents of the gastric secretions with pH<3 were significantly higher than those with pH>4.Conclusion: The resistance to the gastric juice pepsin is decreased by the local defect of the gastric mucus barrier.it may be correlative with gastric ulcer.
出处
《华夏医学》
1999年第2期19-20,共2页
Acta Medicinae Sinica
