急性脑出血性疾病与血浆过氧化脂质、超氧化物岐化酶、谷胱甘肽过氧化物酶关系的研究

Study of the Relation Between Acute Cerebral Hemorrhagic Disease and Plasma Lipoperoxides,Superoxide dismutase and Glutathione Peroxidase

目的：探讨急性脑出血性疾病与血浆过氧化脂质（ＬＰＯ）、超氧化物岐化酶（ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨ－ＰＸ）的关系。方法：用改良硫代巴比妥法、黄嘌呤氧化酶法和谷胱甘肽氧化酶法对４４例急性颅内出血患者血浆ＬＰＯ，ＳＯＤ和ＧＳＨ－ＰＸ含量测定，并以２６例正常对照。结果：急性脑出血患者血浆ＬＰＯ显著高于正常对照（Ｐ＜０．００１），而ＳＯＤ、ＧＳＨ－ＰＸ显著低于正常人组（Ｐ＜０．００１、Ｐ＜０．０５）。ＬＰＯ与ＳＯＤ、ＧＳＨ－ＰＸ呈负相关（ｒ＝－０．２８，ｒ＝－０．３８）。结论：血浆中ＬＰＯ、ＳＯＤ、ＧＳＨ－ＰＸ含量测定对判断急性脑出血性疾病严重程度、评估预后及辅助治疗有一定参与价值。

Objective:To study the relation between acute cerebral hemorrhagic disease and plasma Lipoperoxides(LPO)Superoxide dismutase(SOD) and Glutathione peroxidase(GSHPX).Methods:44 cases patients with acute cerebral hemorrhagic disease and 26 controls were determined by Thiobarbituric acid reaction,Xanthine oxidase test and Glutathione oxidase test.Results:LPO of the patients with acute cerebral hemorrhagic disease was clearly higher than those of the controls(P<0.001) but SOD and GSHPX of the patients were clearly lower than those of the controls (P<0.001,P<0.05),the LPO was negatively correlation with SOD and GSHPX(r=-0.28,r=-0.38). Conclusion:The determination of the plasma LPO,SOD and GSHPX was a referential value to the diagnosis,prognosis and treatment of patients with acute cerebral hemorrhagic disease.