老年高血压病患者不同血压水平血浆部分血管活性肽水平的临床研究

Clinical Study of Plasma Peptides in the Different Period of Elderly Hypertensive Patients

目的：探讨老年高血压病患者血浆中降钙素基因相关肽（ｃＧＲＰ）、心钠素（ＡＮＰ）、内皮素（ＥＴ）的浓度变化与不同程度收缩压水平的关系。方法：采用放射免疫分析方法分别检测８６例老年高血压病患者和３２例正常老年人的ｃＧＲＰ、ＡＮＰ、ＥＴ的浓度，高血压病患者再按收缩压分为三期。结果：血浆ｃＧＲＰ水平随收缩期血压程度的增加而下降，与平均动脉压（ＭＡＰ）呈负相关（ｒ＝－０．６０１２，Ｐ＜０．０５），血桨ＡＮＰ、ＥＴ水平随血压水平升高而升高，与ＭＡＰ呈较好的相关关系（ｒ＝０．６９１５，Ｐ＜０．０１；ｒ＝０．６７５９，Ｐ＜０．０１）。结论：血浆血管活性肽水平是影响高血压病的发生、发展的重要因素。

Objective: To study the relations different period of elderly systolic hypertension (EH) to calcitonin generelated peptide(cGRP) , atrial natriuretic peptide (ANP), endothelin (ET). Methods:Immunoradiometric assay was used to measure the plasma peptides Levels in 86 EH patients,classified into three groups according to systolic blood pressure, and 32 elderly healthy controls.Results:The Levels of plasma cGRP was lower than those of controls, and the cGRP was negatively correlated with mean artery pressure (MAP) (r=-0.6012, P<0.05) ,but the levels of plasma ANP, ET were higher than those of controls , and the ANP,ET were positively correlated with MAP (r=0.6915, P<0.01; r=0.6759, P<0.01). Conclusion: The levels of plasma peptides were the important factors in developing of elderly essential hypertension.