静脉麻醉药抑制心肌作用的机制
摘要
静脉麻醉药大多具有抑制心肌的作用,但确切机制至今尚未完全阐明。本文就静脉麻醉药对心肌直接抑制作用的机制综述如下。1 对收缩蛋白的影响心肌纤维主要含有四种与收缩有关的蛋白质,即肌球蛋白、肌动蛋白、原肌球蛋白和肌钙蛋白。前两者为收缩蛋白,后两者为调节蛋白。心肌细胞兴奋时,肌浆中 Ca<sup>2+</sup>浓度升高。Ca<sup>2+</sup>
参考文献35
-
1Gelissen HPMM,,Epema AH,Henning RH,et al.Inotropic effects of propofol,thiopental,midazolam,etomidate,and ketamine on isolated human atrial muscle. Anesthesiology . 1996
-
2Rusy BF,Komai H.Anesthetic depression of myocardial contractility:a review of possible mechanisms. Anesthesiology . 1987
-
3Mattheussen M,,Housmans PR.Mechanism of the direct,negative inotropic effect of etomidate in isolated ferret ventricular myocardium. Anesthesiology . 1993
-
4Riou B,Viars P,Lecarpentier Y.Effect of ketamine on the cardiac papillary muscle of normal hamsters and those with cardiomyopathy. Anesthesiology . 1990
-
5Riou B,Ruel P,Hanouz JL,et al.ln vitro effects of eltanolone on rat myocardium. Anesthesiology . 1995
-
6Housmans PR,Kudsioglu ST,Biogham J.Mechanism of the negative inotropic effect of thiopental in isolated ferret ventricular myocardium. Anesthesiology . 1995
-
7Veksler VI,Ventura-Clapier R,Lechene P,et al.Functional state of myofibrils,mitochondria and bound creatine kinase in skinned ventricular fibers of cardiomyopathic hamsters. Journal of Molecular and Cellular Cardiology . 1988
-
8Branca D,Vincenti E,Scutari G.Influence of the anesthetic 2,6-diisopropyphenol(propofol)on isolated rat heart mitochondria.Excerpta Medica.Section 24. Anesthesiology . 1995
-
9Komai H,Rusy BF.Differences in the myocardial depressant action of thiopental and halothane. Anesthesia and Analgesia . 1984
-
10Lin Y,Lee C,Lee T,et al.Negative inotropic effects of propofol versus thiopental:Assessment in an isolated ventricular septum model(abstract). Anesthesiology . 1990
-
1Michelle Palmisano Richard L Lieber.骨骼肌的生物力学[J].中华骨科杂志,2007,27(7):551-556. 被引量：1
-
2王小京.基因与青少年肾疾病发作的关联性[J].国外医学情报,2003,24(4):20-20.
-
3吴卫春,王胜利,张丽萍,尤虹力,方春春.腺苷预处理对人未成熟心肌缺血再灌注损伤的保护作用机制[J].浙江医学,2008,30(7):685-688.
-
4张群,钱云良,崔磊.瘢痕中肌动蛋白及肌球蛋白的实验研究[J].中国修复重建外科杂志,2001,15(1):32-35. 被引量：6
-
5泌尿科学 泌尿生殖系疾病[J].国外科技资料目录（医药卫生）,1998(1):100-100.
-
6泌尿科学(泌尿生殖系疾病)[J].国外科技资料目录（医药卫生）,1997(3):104-104.
-
7李跃华,孔丽萍,巩性军,陈凡.心内直视手术中腺苷预处理保护心肌作用的临床观察[J].山东医药,2003,43(30):21-22.
-
8张进生,柳建垒,刘宁,渠渊,罗静,吴宗山,冯超,张前,柴军,刘春林.前列腺增生患者逼尿肌收缩蛋白变化的研究[J].北京医学,2013,35(7):539-541.
-
9李德闽,汪曾炜,易定华.温血间断停灌对心肌肌浆网摄钙功能的影响[J].中国胸心血管外科临床杂志,1999,6(4):235-238.
-
10周越,任媛媛,王瑞元.大鼠股直肌去负荷萎缩及再负荷恢复过程中的蛋白表达差异[J].中国运动医学杂志,2011,30(6):536-541. 被引量：1
