摘要
Objective: To investigate the pharmaceutical effect of Spatholobus Suberectus Composita (SSC) on bone marrow hematopoiesis andmicroenvironment of aplastic anemia. Methods: One hundred and six cases of aplastic anemia patients were treated by SSC and thepathological change of bone marrow were observed before and after treatment for 24months, and compared with 17 cases of normal volunteers as the control. Results: Thetotal effective rate was 77. 4 %. The degree ofmarrow hyperplasia (15. 7 ±10. 2 vol% vs39. 2 ±13. 9 vol% ), the percentage of thegranulocytes (31. 4 ±12. 4% vs 39. 9±10.4% ), the erythroblastes (19. 8 ±15. 9 % vs36. 7±13. 5 % ), megakaryocytes (1. 4 ±2. 3cells/section vs 24. 0 ±24. 6 cells/section),and the microvessel number (40. 0±23. 4 ves/100 mm2 vs 201. 0 ±141. 0 ves/100 mm2) ascended significantly (P < 0. 01 or P < 0. 05).Conclusion: SSC could not only irritate thehematopoiesis, but also exert reconstructiveaction to marrow microenvironment.
Objective: To investigate the pharmaceutical effect of Spatholobus Suberectus Composita (SSC) on bone marrow hematopoiesis andmicroenvironment of aplastic anemia. Methods: One hundred and six cases of aplastic anemia patients were treated by SSC and thepathological change of bone marrow were observed before and after treatment for 24months, and compared with 17 cases of normal volunteers as the control. Results: Thetotal effective rate was 77. 4 %. The degree ofmarrow hyperplasia (15. 7 ±10. 2 vol% vs39. 2 ±13. 9 vol% ), the percentage of thegranulocytes (31. 4 ±12. 4% vs 39. 9±10.4% ), the erythroblastes (19. 8 ±15. 9 % vs36. 7±13. 5 % ), megakaryocytes (1. 4 ±2. 3cells/section vs 24. 0 ±24. 6 cells/section),and the microvessel number (40. 0±23. 4 ves/100 mm2 vs 201. 0 ±141. 0 ves/100 mm2) ascended significantly (P < 0. 01 or P < 0. 05).Conclusion: SSC could not only irritate thehematopoiesis, but also exert reconstructiveaction to marrow microenvironment.
