^(99m)锝-甲氧基异丁基异腈心肌灌注显像对冠心病诊断的临床评价-同冠状动脉造影对比

A clinical assessment of ^(99m)Tc - MIBI myocardial perfusion SPECT in the diagnosis of patients coronary artery disease

目的探讨^（99m）锝-甲氧基异丁基异腈心肌灌注显像对冠心病诊断价值。方法对126例怀疑冠心病的患者进行了结合运动试验和多巴酚丁胺负荷的^（99m）锝-甲氧基异丁基异腈心肌灌注显像（^（99m）Tc－SPECT），并同冠状动脉造影检查对比研究。结果显示^（99m）Tc－MIBI-SPECT对冠心病的诊断敏感性和特异性分别为91．2％和88．6％；对单支、双支和三支冠脉病变的敏感性分别为88．5％、92．3％和100％；对前降支、回旋支和右冠状动脉病变的检出率分别为92．6％、85．7％和81．8％。结论结合运动试验和多巴酚丁胺负荷的^（99m）Tc－MIBI－SPECT是一种对冠心病诊断和定位有较大价值的检查方法，且具有无创伤性、高敏感性和特异性。

Purpose The study intendedto assess the value of 99mTc- MIBI myocardial perfusion SPECT in the diagnosis of coronary artey disease (CAD). Methods 99m Tc - MIBI myocardialperfudion SPECT in combination with stress test anddobutamine challenging were Performed in 126 Patients with possible CAD. Then, all patients wereundertaken coronary angiography to confirm the diagnosis. Results The sensitivity and specificity ofSPECT for detecting Pateints with coronarydisease were 91.2% and 88.6%, respectively. Inaddition, its sensitivity in identifying the patientswith one - vessel, two - vessel and three- vesselstenosis was 88.5%, 92.3% and loo%, respectively. Furthermore, the sensitivity of SPECT for detecting the leisions of LAD, LCX and RCA was92.6%, 85.7% and 81 .8%, respectively. Conclusion 99mTc- MIBI myocardial perfusion SPECT incombination with stress test and dobutamine challenging is a valuable non - invasive method withhigh sensitivity and specificity for the diagnosis andlocalization of CAD.[