期刊文献+

糖耐量受损和2型糖尿病患者血清C反应蛋白与脂联素的水平及相关性 被引量:1

下载PDF
导出
摘要 目的探讨血清C反应蛋白(CRP)与脂联素在糖耐量受损(IGT)和2型糖尿病(T2DM)患者中的水平及其相关性。方法选取56例IGT患者、55例T2DM患者及50例健康对照组人群作为研究对象,分别测定血清CRP、脂联素、总胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇、血糖、胰岛素,血压、身高、体重、腰围、臀围,计算体重指数,采用MINIMOD计算机软件包计算胰岛素敏感指数(SI)及急性胰岛素反应(AIR),并进行分析比较。结果 T2DM组、IGT组血清CRP分别为(2.46±0.25)mg/L、(3.12±0.46)mg/L,对照组为(0.46±0.21)mg/L,前者显著高于后者;T2DM组、IGT组血清脂联素分别为(3.49±1.21)mg/L、(4.13±1.54)mg/L,对照组为(7.81±2.65)mg/L,前者显著低于后者。T2DM组和IGT组SI及AIR显著低于对照组,甘油三酯及低密度脂蛋白胆固醇显著高于对照组,差异均有统计学意义(P<0.05);CRP与脂联素、AIR和SI呈负相关,脂联素与AIR和SI呈正相关(P<0.05)。结论血清CRP与脂联素在IGT和T2DM患者血清中表达发生异常改变,且与患者胰岛素抵抗密切相关,检测其血清水平对预测疾病预后及指导早期干预意义重大。
作者 秦卫红
出处 《中国老年学杂志》 CAS CSCD 北大核心 2011年第21期4119-4120,共2页 Chinese Journal of Gerontology
  • 相关文献

参考文献8

二级参考文献48

  • 1朱麒钱,尤巧英,李成江,李红,沈建国,斯徐伟,官莉莉,俞钟明,楼大均,金华伟.C反应蛋白与2型糖尿病大血管病变危险因素的相关性研究[J].中华内分泌代谢杂志,2005,21(4):320-321. 被引量:104
  • 2Saitok, TobeT, MinoshimaS, et al Adiponectin Ⅱ 64 T mutation is associated with the metabo lic syndrome and coronary artery disease [ J]. Jam Coll Cardiol,2004 ;43 (7) : 1195-1200.
  • 3Matsubara M, Maruoka S, Katayose S. et al. Decreased plasma adiponectin concentra - tions in women with dyslipidemia [ J]. J Clin Endocrinol Metab ,2002,87 (6) :2764-2769.
  • 4Naderll EK, Shimadak, Fukuda D, et al. Implications of plasma Concentrations of adiponectin in patients wit coronary artery disease [J]. Heart, 2004,90 ( 5 ) :528-533.
  • 5Maeda N, Shimomura I, Kishida K, et al. Diet - induced insulin resistance in mice lacking adiponctin/ACRP30 [ J ]. Nat Med, 2002,8 (7) :731-737.
  • 6Ouchi N, Kihara S , Arita Y, et al .. Novel modulator for en - dothelial adhesion molecules: adipocyte-derved palsrns pro-tein adiponectida[J]. Circualtion, 1999,100(26) :2473-2476.
  • 7Arita Y, Kihara S, Ouchi N , et al. Adipocyte - derived plas - ma protein adiponectin acts as a platelet-derived growth fac-tor-BB- binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell [ J]. Circulation, 2002, 105 (24) :2893-2898.
  • 8Ouchie N, Kihara S, Arita Y, et al. Adipocytederived plas-ma protein , adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages[J]. Circulation ,2001,103 ( 8 ) : 1057-1063.
  • 9Daimon M,Oizumi T,Smtoh T,et al.Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Jspanese Population:the Futmgata study[J].Diabetes Care,2003,26(7):2015-2020.
  • 10Yaturu S,Bridges JF,Subba Reddy DR.Decreased levels of plasma adiponectin in prediabetes,Type 2 diabetes and coronary artery disease[J].Med Sci Monit,2006,12(1):CR17-20.

共引文献79

同被引文献4

  • 1HotamisligilGS. Endoplasmic reticulum stress and the inflammatory ba- sis of metabolic disease. Cel,1 2010,140 (6) : 900 -917.
  • 2Goldberg RB. Cytokine and cytokine - like inflammation markers, en-dothelial dysfunction, and imbalanced coagulation in development of diabetes and its complications , J Clin EndocrinolMetab, 2009, 94 (9) : 3171 -3182.
  • 3Langenberg C, Bergstrom J, Scheidt - Nave C, et al. Cardiovascular death and the metabolic syndrome:role ofadiposity-signaling hormones and inflamm-atory makers Diabetes Care ,2006,29 ( 6 ) : 1363 - 1369.
  • 4单莉,洪云.血清脂联素与2型糖尿病及其大血管病变的相关性研究[J].中国综合临床,2010,26(6):605-607. 被引量:11

引证文献1

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部