期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

丹红注射液对脑梗死患者氧化低密度脂蛋白及基质金属蛋白酶-2水平的影响 被引量：2

下载PDF
导出
摘要 目的探讨脑梗死患者丹红注射液治疗前后血清氧化低密度脂蛋白(ox-LDL)、基质金属蛋白酶(MMP-2)水平的变化。方法选择住院治疗的急性脑梗死病人15例,给予0.9%生理盐水250 ml加丹红注射液40 ml每日1次静点,且在入院时及药物治疗后2 w分别检测ox-LDL,MMP-2的抗体水平。结果丹红注射液治疗前ox-LDL、MMP-2水平分别为(43.94±25.20)、(25.84±14.10)μg/dl,治疗后水平分别为(31.25±24.45)、(21.12±7.82)μg/dl,治疗前后血清ox-LDL含量有显著变化(P<0.05)。结论丹红注射液从抗氧化的角度,对急性脑梗死的治疗起重要作用。
作者 姚建华 宋春伶 杨鑫
机构地区 吉林大学白求恩第二医院神经内科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2011年第21期4144-4145,共2页 Chinese Journal of Gerontology
关键词 丹红注射液 脑梗死 氧化低密度脂蛋白 基质金属蛋白酶
分类号 R743 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献7

二级参考文献24

  • 1各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量：33009
  • 2Rosell A,Ortega-Aznar A,Alvarez-Sabin J,et al.Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke[J].Stroke,2006,37(2):1399.
  • 3Gasche Y,Soccal PM,Kanemitsu M,et al.Matrix metalloproteinases and diseases of the central nervous system with a special emphasis on ischemic brain[J].Front Biosci,2006,11:1289.
  • 4Gao D,Zhang X,Jiang X,et al.Resveratrol reduces the elevated level of MMP-9 induced by cerebral ischemia-reperfusion in mice[J].Life Sci,2006,78(22):2564.
  • 5Wang L,Zhang ZG,Zhang RL,et al.Matrix metalloproteinase-2(MMP-2) and MMP-9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration[J].J Neurosci,2006,76(22):5996.
  • 6Fang HY,Ko WJ,Lin CY.Inducible heat shock protein 70,interleukin-18,and tumor necrosis factor alpha correlate with outcomes in spontaneous intracerebral hemorrhage[J].J Clin Neurosci,2007,14(5):435.
  • 7Rodriguez-Galan MC,Bream JH,Farr A,et al.Synergistic effect of IL-2,IL-12,and IL-18 on thymocyte apoptosis and Th1/Th2 cytokine expression[J].J Immunol,2005,174(5):2796.
  • 8Okamoto M,Kato S,Oizumi K,et al.Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung injury in mice:a potential role for cytokines,chemokines,and natural killer cells in the pathogenesis of interstitial pneumonia[J].Blood,2002,99(4):1289.
  • 9Schmitz T,Heep A,Groenendaal F,et al.Interleukin-1beta,interleukin-18,and interferon-gamma expression in the cerebrospinal fluid of premature infants with posthemorrhagic hydrocephalus--markers of white matter damage[J].Pediatr Res,2007,61(6):722.
  • 10Holland N,Dong J,Garnett E,et al.Reduced intracellular T-helper 1 interferon-gamma in blood of newly diagnosed children with Crohn's disease and age-related changes in Th1/Th2 cytokine profiles[J].Pediatr Res,2008,63(3):257.

共引文献440

同被引文献26

  • 1刘春霞,张建平,代全德,赵明.颈动脉硬化斑块与血浆高敏C-反应蛋白、基质金属蛋白酶-2/9、CD40配体水平的关系[J].中华临床医师杂志（电子版）,2011,5(8):2262-2265. 被引量：19
  • 2王薇薇,王新德.第六届全国脑血管病学术会议纪要[J].中华神经科杂志,2004,37(4):346-348. 被引量：298
  • 3Jacob-Ferreira AL, Schulz R. Activation of intracellular matrix metalloproteinase-2 by reactive oxygen-nitrogen species:consequences and therapeutic strategies in the heart [J]. Arch Biochem Biophys, 2013,540 (1-2) : 82-93.
  • 4Halder AK, Saha A, Jha T. Exploring QSAR and pharma- cophore mapping of structurally diverse selective matrix metalloproteinase-2 inhibitors[J]. J Pharm Pharmacol, 2013, 65(10) : 1541-1554.
  • 5薛爽,魏坤,杨丽红,等.rtPA静脉溶栓治疗急性脑梗死的血流动力学监测[C].第七届全国颅脑及颈动脉超声学术会议论文集.昆明:中国超声医学工程学会,2007:97-100.
  • 6杨益挺,陶沂,管阳太,等.TCD评价颅内动脉侧枝循环的形成对脑梗死静脉溶栓预后的影响[J].中国中医药科技,2014,21(z2):171-172.
  • 7Massot A, Pelegri D, Penalba A, et al. Lipoprotein- associated phospholipase A2 testing usefulness among patients with symptomatic intracranial atherosclerotic disease. [J]. Atherosclerosis, 2011, 218(1): 181-187.
  • 8Wijnhoud A D, Koudstaal P J, Dippel D W. The prognostic value of pulsatility index, flow velocity, and their ratio, measured with TCD ultrasound, in patients with a recent TIA or ischernic stroke. [J]. Acta Neurol Scand, 2011, 124(4): 238-244.
  • 9Suri M F, Georgiadis A L, Tariq N, et al. Estimated prevalence of acoustic cranial windows and intracranial stenosis in the US elderly population: ultrasound screening in adults for intracranial disease study. [J]. Neuroepidemiology, 2011, 37(1): 64-71.
  • 10柯将琼,黄健康,王小同,李勇,郑国庆,林巍.三种量表预测自发性脑出血患者预后的研究[J].中国脑血管病杂志,2008,5(5):199-202. 被引量：11

引证文献2

二级引证文献15

中国老年学杂志
2011年 第21期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部