健康男性成人血清α_1-酸性糖蛋白浓度及其与年龄的相互关系

α 1 acid glycoprotein concentrations in serum of male healthy subjects and the age related changes

目的：研究健康男性成人血清α１－酸性糖蛋白（α１－ＡＧＰ）的浓度范围及其与年龄的关系。方法：采用免疫比浊法，测定了经临床实验室检查证实健康的２１３例男性成人血清α１－ＡＧＰ浓度。结果：青年组（１８～２３岁，ｎ＝１７２）和非青年组（２４～５９岁，ｎ＝４１）男性血清α１－ＡＧＰ浓度分别为５６３．９±２９．５ｍｇ／Ｌ（范围４４４．５～６１８．０ｍｇ／Ｌ），５６４．５±３２．７ｍｇ／Ｌ（范围４６０．９～６４７．５ｍｇ／Ｌ）。两组比较，血清α１－ＡＧＰ浓度无显著差异（Ｐ＞０．０５）。α１－ＡＧＰ浓度的９５％参考值范围为下限５０５．０ｍｇ／Ｌ，上限为６２３．０ｍｇ／Ｌ。回归分析表明，２１３例健康男性的血清α１－ＡＧＰ浓度与年龄无相关性（ｒ＝０．０３５３，Ｐ＞０．０５）。结论：健康男性成人９５％以上的个体，血清α１－ＡＧＰ浓度在５０５．０～６２３．０ｍｇ／Ｌ之间，较高的α１－ＡＧＰ浓度提示存在某种疾病或病理状态。健康男性成人血清α１－ＡＧＰ浓度与年龄无关。

Objectives:To study the range of α 1 acid glycoprotein(α 1 AGP) concentrations in serum of male healthy subjects and the age related changes. Methods: Based on the clinical laboratory tests, serum α 1 AGP concentrations were determined by immuno nephelometry method in 213 male healthy srbjects. Results: Serum α 1 AGP concentrations in young man group(18￣23 years old, n =172) and in non young man group(24￣59 years old, n =41) were 563. 9±29.5 mg/L (range 444.5￣618.0 mg/L) and 564.5 ±32.7 mg/L (range 460.9￣647.5 mg/L), respectively. There was no significant difference in α 1 AGP concentrations in the two groups ( P >0.05). The range of α 1 AGP concentration ( x± 1.96 s ) in 213 male healthy subjects was 505.0 mg/L for lower limit and 623.0 mg/L for upper limit. Regression analysis revealed that there was no relationship between the concentrations of serum α 1 AGP and the age in 213 healthy man ( r = 0.035 3 , P >0.05). Conclusions: The serumα 1 AGP is maintained in a lower level in the male healthy subjects. The elevated α 1 AGP concentrations in serum suggest the presedce of some disease states or pathophysiological conditions. The α 1 AGP concentrations in healthy male subjects do not correlate with the age.