摘要
Calcitonin gene-related peptide（CGRP）has the effect of antiarrhyth-mic,expectally to ischemtc arrhythmia.But up to now,it’s electro-physiological mechanism is not known very clearly.In this study,theaction potential and resting membrane potential（RP）in rabbit my-ocardial were recorded with standard glass microelectrodes tech-nique,the electrophysiotogical effects of CGRP on normal and simu-lated ischemtc condition were observed.The results showed that:（1）In normal condition,after afflication of CGRP(the concentration ofCGRP was 1×10<sup>-8</sup>M,CGRP was purchased from sigma chemicalCo),RP and action potential amplltude（APA）increased significantly（P【0.01）,the action potential duration(APD<sub>30</sub>,APD<sub>50</sub>)were notchanged obviously,but the APD<sub>90</sub>was shorted obviously（P【0.05）.（2）In simulated ischemic condition,CGRP had the same effects onRP and APA as normal condition.It prolonged the APD<sub>30</sub>and APD<sub>50</sub>obviously（P【0.05）and shorted the APD<sub>90</sub>signficantly.This indicat-ed that CGRP could reverse the abnormal changes caused by ischemi-a.These results demonstrated that CGRP had stabilizing and protec-tive effects on ischemical myocardial.
Calcitonin gene-related peptide(CGRP)has the effect of antiarrhyth- mic,expectally to ischemtc arrhythmia.But up to now,it's electro- physiological mechanism is not known very clearly.In this study,the action potential and resting membrane potential(RP)in rabbit my- ocardial were recorded with standard glass microelectrodes tech- nique,the electrophysiotogical effects of CGRP on normal and simu- lated ischemtc condition were observed.The results showed that:(1) In normal condition,after afflication of CGRP(the concentration of CGRP was 1×10^(-8)M,CGRP was purchased from sigma chemical Co),RP and action potential amplltude(APA)increased significantly (P<0.01),the action potential duration(APD_(30),APD_(50))were not changed obviously,but the APD_(90)was shorted obviously(P<0.05). (2)In simulated ischemic condition,CGRP had the same effects on RP and APA as normal condition.It prolonged the APD_(30)and APD_(50) obviously(P<0.05)and shorted the APD_(90)signficantly.This indicat- ed that CGRP could reverse the abnormal changes caused by ischemi- a.These results demonstrated that CGRP had stabilizing and protec- tive effects on ischemical myocardial.
出处
《中国介入心脏病学杂志》
1998年第4期189-189,共1页
Chinese Journal of Interventional Cardiology
