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Angiographical and histopathologic study of atherosclerotic plaques in acute myocardial infarction

Angiographical and histopathologic study of atherosclerotic plaques in acute myocardial infarction
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摘要 Objective Compare the morphology of atherosclerotic plaquesmgiographically and histopathologically in acute myocardialmfarction m order to accumulate experience in recognizing plaquerupture and thrombus by angiogrames.Material and methods 16postmortem cases of acute myocardial infarction were studied.The coronary arteries were romoved en block,filled with barium the lumen and ridiographed.Then the arteries wereontinuously insetted and routin HE sections were made.Results 16 cases had plaque ruptures and thrombi.Among the total98 blocks,21 had plaque ruptures on which 20 thrombiccur(95.23%).while the other 777 unrupured blocks had only 2hrombi(0.25%).The difference was significant(p【0.001).Therupture mostly occur on unstable plaques.The ruptured plaqueswith thrombi had different angiographical morphology withunruptured plaques.The former had irregular borders andunraluminal lucencies;while the Iatter had smooth borders and nointraluminal lucencies.Conclusions Plaque ruprure withthrumbus was the major cause of acute myocardial infarction andthe ruptured plaques with thrombus had different angiographicalapperances with unruptured plaques. Objective Compare the morphology of atherosclerotic plaques mgiographically and histopathologically in acute myocardial mfarction m order to accumulate experience in recognizing plaque rupture and thrombus by angiogrames.Material and methods 16 postmortem cases of acute myocardial infarction were studied. The coronary arteries were romoved en block,filled with barium the lumen and ridiographed.Then the arteries were ontinuously insetted and routin HE sections were made.Results 16 cases had plaque ruptures and thrombi.Among the total 98 blocks,21 had plaque ruptures on which 20 thrombi ccur(95.23%).while the other 777 unrupured blocks had only 2 hrombi(0.25%).The difference was significant(p<0.001).The rupture mostly occur on unstable plaques.The ruptured plaques with thrombi had different angiographical morphology with unruptured plaques.The former had irregular borders and unraluminal lucencies;while the Iatter had smooth borders and no intraluminal lucencies.Conclusions Plaque ruprure with thrumbus was the major cause of acute myocardial infarction and the ruptured plaques with thrombus had different angiographical apperances with unruptured plaques.
出处 《中国介入心脏病学杂志》 1998年第4期193-193,共1页 Chinese Journal of Interventional Cardiology
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