肝硬化患者血清透明质酸测定与Child分级的关系

Relationship Between Determination of Serum Hyaluronic Acid of Patients With Hepatocirrhosis and Child's Grading

为探讨肝硬化患者血清透明质酸ＨＡ与Ｃｈｉｌｄ分级的关系，用放免法测定５８例肝硬化患者血ＨＡ含量，并与Ｃｈｉｌｄ分级主要指标进行比较。结果肝硬化患者血ＨＡ浓度明显增高，随肝功能Ｃｈｉｌｄ分级加重而递增，Ａ、Ｂ、Ｃ各级间ＨＡ值有显著性差异（Ｐ＜０．０１，Ｐ＜０．０５）。血ＨＡ值与白蛋白呈负相关，与总胆红素、丙氨酸转氨酶呈正相关。

In order to probe into the relationship between serum hyaluronic acid (HA) of patients with hepatocirrhosis and Child's grading,the serum HA contents of 58 patients with cirrhosis were determined by radioimmunoassay and compared with the main indexes of Child's grading. The results showed that the concentration of serum HA of patients with cirrhosis was markedly high and increased along with the exacerbation of liver function of Child's grading,the HA values between A,B,C gradings had significant difference (P<0.01,P<0.05).The serum HA value showed negative correlation with albumin and positive correlation with total bilirubin and alanine transaminase.It is considered that the concentration of serum HA may serve as the reference index in differentiating the degree of liver diseases of Child's grading and prognosis.