摘要
对40例肝细胞肝癌患者血清细胞间粘附分子1(sICAM1)测定的结果显示:患者平均sICAM1水平为1905ng/ml,明显高于正常对照的303ng/ml(P<0.01),40例中血清甲胎球蛋白(AFP)阴性和低持阳的15例,其sICAM1也呈阳性。7例外科切除术后AFP持续阴性4~18月者,血清sICAM1水平高于正常两倍以上,进一步随访全部复发。结果提示血清sICAM1水平的测定有助于肝细胞肝癌的早期诊断和复发监测。
Levels of circulating intercellular adhesion molecule1(ICAM1) were meassured in 40 patients with hepatocellular carcinoma(HCC).The results showed that the mean value of sICAM1 in HCC was 1 905ng/ml which was significantly higher than the 303ng/ml of the control(P<0.01).The mean value of ICAM1 in 15 cases whose serum AFP were negative was also higher than 1 700ng/ml.During the follow up of 4~18 months,7 patients who under went a hepatectomy showed that serum AFP were negative,but the levels of sICAM1 were two times higher than normal and further examination showed that all of 7 cases had a recurrence of the tumor. The stydues have demonstrated that detecting circulating ICAM1 is of great value in early diagnosis and monitoring rccurrence of hepatocellular carcinoma.
出处
《华夏医学》
1998年第2期7-8,共2页
Acta Medicinae Sinica
关键词
SICAM-1
肝细胞
肝癌
诊治
sICAM1
hepatocyte
hepatic carcinoma
diagnosis and treatment