陈旧性心肌梗塞患者凝血纤溶状态的研究

Study of Coagulation and Fibrinolysis in Patients with Old Myocardial Infarction

测定了16例陈旧性心肌梗塞（OldMyocardialInfarction，OMI）患者凝血、纤溶分子标记物及血栓弹力图，并与正常人及急性心肌梗塞（AcuteMyocardialInfarction，AMI）患者作了比较。结果表明：OMI患者凝血激活分子标志物凝血酶─抗凝血酶Ⅲ复合物及血纤维蛋白肽A均高于正常对照组（P<0．05），但低于AMI组（P<0．05），OMI组纤溶指标D—D二聚体高于正常对照组（P<0．05），但低于AMI组（P<0．05）、OMI组其TEG之r值及k值较正常对照组明显缩短（P<0．05），而与AMI组无差异。OMI组Ma值大于正常对照组（P<0．01），而与AMI组无差异。

Thrombin-antithrombin Ⅲ complex (TAT), Fibrin peptide A (FPA) .D-D dimer. a2-PI andThromboelastograph (TEG) in OMI patients were detected and the results were compared with patients withAMI and normal control. It was shown that the levels of TAT.FPA and D-D dimer in OMI were significantlyhigher than those in normal control (P<0. 05) and lower than those in AMI(P<0. 05). The r value and kvalue in OMI were significanly shorter than those in normal control (P< 0. 05), while Ma value was significantly higher than that in normal control (P< 0.01 ). The results suggest that the coagulation activationand fibrin formation exist in the patients with OMI.