摘要
观察肾功能、肾皮质、红细胞超氧化物歧化酶（SOD）、血浆过氧化脂质（LPO）、残肾形态学等指标，发现黄丹胶囊可以延缓5／6肾切除大鼠血尿素氮（BUN）、血肌酥（Scr）增高［黄丹胶囊（8．82mg／kg）组BUN（12．51±3．54）mmol／L，Scr（16．81±30．37）μmol／L；覆醛氧化淀粉组BUN（18．18±3．85）mmol／L，Scr（217．34±41．61）μmol／L］（P＜0．001），提高肾皮质、红细胞SOD（P＜0．01），降低血浆LPO（P＜0．01），延缓肾脏病理改变，从而延缓慢性肾衰的进程。
in this study, we observed the renal function, activities of superoxide dismutase (SOD) in renal cortex and erythrocyte, lipid peroxide(LPO) in plasma, and the morphology of remnant kindey. The results showed that Huangdan capsules could lower down the increase of BUN and Scr [in Huangdan capsule(8. 82 mg/kg) BUN (12. 51± 3. 54) mmol/L, Scrl (64. 81 ±30. 37) umol/L, in Group E, BUN (18. 18±3. 85 ) mmol/L, Scr2 (17. 34±41. 610 umol/L] (P <0. 001 ), elevate the SOD activity, reduce thd level ofLPO (P<0. 01,0. 01 ), and delay the renal pathological changes in 5/6 nephrectomized rats, thus delayingthe pathological progress of chronic renal failure.
出处
《华中科技大学学报（医学版）》
CAS
CSCD
1998年第4期290-292,共3页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
