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THE EXPERIMENTAL RESEARCH ON CARDIOPLEGIC SOLU-TION CONTAINING SELENIUM AND MAGNESIUM AGAINST MYOCARDIAL ISCHEMIA REPERFUSION DAMAGE

THE EXPERIMENTAL RESEARCH ON CARDIOPLEGIC SOLU-TION CONTAINING SELENIUM AND MAGNESIUM AGAINSTMYOCARDIAL ISCHEMIA REPERFUSION DAMAGE
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摘要 The model of this test was set up according to Langendoff isolated heart reperfusion mechanics. The experimental research was designed to observe the protective effects on ischemic andreperfuslon myocardial tissue by using ST. Thomas cardioplegic solution containing selenium andmagnesium. We conclude that using cold crystallold cardioplegic solution containing Se'+, Mg' 4 canobviously reduce ischemic and reperfusion myocardlal injury and bas an advantage of recovering myocardial runctlon after operation by observing the content or lactic dehydrogenase (LDH); creatineI,kasphoklnase CK in the coronary vessel's sinus reflux solutlonl glutatblone peroxldase (GPX); suI,eroxlde dismutase (SOD); maloydladehyde (MDA ) I Se4+ .Mg'+ .Ca'+ and cia-nging or myocardialultrastructure. The model of this test was set up according to Langendoff isolated heart reperfusion mechanics. The experimental research was designed to observe the protective effects on ischemic andreperfuslon myocardial tissue by using ST. Thomas cardioplegic solution containing selenium andmagnesium. We conclude that using cold crystallold cardioplegic solution containing Se'+, Mg' 4 canobviously reduce ischemic and reperfusion myocardlal injury and bas an advantage of recovering myocardial runctlon after operation by observing the content or lactic dehydrogenase (LDH); creatineI,kasphoklnase CK in the coronary vessel's sinus reflux solutlonl glutatblone peroxldase (GPX); suI,eroxlde dismutase (SOD); maloydladehyde (MDA ) I Se4+ .Mg'+ .Ca'+ and cia-nging or myocardialultrastructure.
出处 《Journal of Pharmaceutical Analysis》 CAS 1998年第1期22-27,共6页 药物分析学报(英文版)
关键词 SELENIUM MAGNESIUM oxygen free radicals (OFR) calcium overload RAT isolated heart ischemia/reperfusion damage selenium magnesium oxygen free radicals (OFR) calcium overload rat isolated heart ischemia/reperfusion damage
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参考文献6

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二级参考文献2

  • 1王凡,李广生,康德仁,张保国,杨青,盖晓东.克山病病因研究新进展[J].中国地方病学杂志,1989,8(1):52-55. 被引量:62
  • 2徐光禄,薛文岚,张培毅,封楚芬,洪善扬,梁文昇.克山病病区与非病区人群饮食硒含量和机体硒状态[J]营养学报,1982(03).

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