Bile acids in serum and bile of patients with cholesterol gallstone

ＢｉｌｅａｃｉｄｓｉｎｓｅｒｕｍａｎｄｂｉｌｅｏｆｐａｔｉｅｎｔｓｗｉｔｈｃｈｏｌｅｓｔｅｒｏｌｇａｌｓｔｏｎｅＨＡＮＴｉａｎＱｕａｎ１，ＺＨＡＮＧＳｈｅｎｇＤａｏ１，ＴＡＮＧＷｅｎＨａｏ２ａｎｄＪＩＡＮＧＺｈａｏＹａｎ１Ｓｕｂｊｅｃｔｈｅ...

IM To analyze serum bile acids and biliary lipids of patients with cholesterol gallstone(CS) and explore the relationship between deoxycholic acid (DCA) and CS disease.METHODS Analysis of bile acids in serum was done with gaschromatography in two groups: CS group (n=151) and control group (n=256). Serum bile acids and biliary lipids were also studied in 90 matched samples..RESULTS The serum DCA was 0955μmol/L±0078μmol/L in CS group, which was more than that of control group (0696μmol/L±0047μmol/L), P<001. The ratio of DCA/chenodeoxycholic acids (CDCA) was 176±030 in CS group, about two times that in control group (092±014). The mole percent of DCA in bile was positively related to cholesterol saturation index (CSI) (P<001) and the mole percent of CDCA in bile negatively to CSI (P=001). There was correlation between the mole percent of DCA, CDCA and cholic acid in bile and in serum.CONCLUSION It is suggested that DCA is lithogenic and the increased amount of DCA or the ratio of DCA/CDCA in serum may be one of the features of cholesterol gallstone patients.