摘要
The preliminary studies of the effects of lanthanides(Lns) on hemoglobin are reported. It has been revealed that Ln ions reduce the oxygen saturation of hemoglobin and the oxygen releasing potency of oxyhemoglobin under reduced partial pressure of oxygen. The Ln ions do not replace the iron atom in the heme probably due to the conformational change of hemoglobin induced by Ln binding, which was investigated by circular dichroism(CD) and fluorescence spectra.
The preliminary studies of the effects of lanthanides(Lns) on hemoglobin are reported. It has been revealed that Ln ions reduce the oxygen saturation of hemoglobin and the oxygen releasing potency of oxyhemoglobin under reduced partial pressure of oxygen. The Ln ions do not replace the iron atom in the heme probably due to the conformational change of hemoglobin induced by Ln binding, which was investigated by circular dichroism(CD) and fluorescence spectra.
