心肌组织和血浆IGF—Ⅰ的相关性

A study on the relationship of the level of IGF - I between heart tissue and blood plasm Cao Heng Rui Shibao

本研究采用放射免疫分析法测定自发性高血压大鼠(SHR)和正常血压的Witar—Kyoto大鼠(WKY)血浆和心肌组织中的IGF—Ⅰ水平,以心脏混重(HW)和心脏混生/体重(HW/BW)来判定心肌肥厚。结果显示:SHR的HW较WKY有显著升高(P<0.05),HW/BW则较WKY有高度显著升高(P<0.01)。两组大鼠心肌组织中IGF—Ⅰ与血浆中的IGE—Ⅰ显示正相关(WKY:r=0.8485,P<0.05;SHR:r=0.9529,P<0.005);试验结果提示不论心脏生理和病理情况下,心脏合成和分泌的IGF—Ⅰ对循环中的IGF—Ⅰ水平均有影响,而在心肌肥厚,心肌组织中的IGF—Ⅰ病理水平增高时,影响更为明显。

In this study the level of insulin - like growth factor I (IGF - I) in hearttissue and plasm of spontaneously hypertensive rats ( SHR ) and Wistar - Kyoto rats ( WKY ) was measured with radioimmunoassay. The heart hypertrophy was determinded by the heart weight (HW) and heart weight/body weight (HW/BW) . It was showed that HW was higher (P<0. 05) in SHR than in WKY, and the HW/ BW was much higher (P<0. 01) in SHR than in WKY. There were a positive correlation between the level of IGF - I in heart and in plasm (WKY: r= 0. 84S5P<0. 05, SHR. r= 0. 9529P<0. 005) . The above results suggest that the level of IGF - I in blood is affected by the IGF- I produced in heart regardless of whether the heart is physiologic or pathologic. There is a positive correclation between them.