摘要
ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅｃｏｍｂｉｎｅｄｃｈｅｍｏｔｈｅｒａｐｙｆｏｒｍａｌｉｇｎａｎｔｃａｒｃｉｎｏｍａｉｓｄｅｓｉｒｅｄｔｏｐｒｏｄｕｃｅｅｆｉｃａｃｉｏｕｓｓｙｎｅｒｇｉｓｍｂｅｔｗｅｅｎｅａｃｈｄｒｕｇ，ａｌｅｖｉａｔｅｓｉｄｅｅｆｆｅ...
AIM To evaluate the killing effects of CDDP, 5-Fu and VCR on human hepaoma cell line (7721).METHODS The median-effect principle was used.RESULTS Killing effects of the individual drug were enhanced as the median concentration increased. Antagonism was produced when two drugs were used at a higher concentration (CI＞1), and synergism was achiened when CI＜1. Finally, the effect was influenced by both the ratios of drug concentration and the sequence of administration.CONCLUSION The drug administration order and drug concentrations are significant factors that need to be considered in clinical practice.INTRODUCTIONThe combined chemotherapy for malignant carcinoma is desired to produce efficacious synergism between each drug, alleviate side effects of drugs and delay drug resistance. Clinically, the interaction (namely synergism, summation and antagonism) of different anticancer drugs in combination is usually evaluated by Chou-Talalay′s combination index (i.e., median-effect principle)[1-9]. In this paper the combination effect between Cisplatin (Cis), 5-Fluorouracil (5-Flu) and Vincristine (VCR) on human hepatoma cell line 7721, was analyzed in vitro.
