摘要
观察血液灌流对重症急性胰腺炎(SAP)大鼠血液中细胞因子的影响.方法:采用经胰管注射牛黄胆酸钠制造大鼠SAP模型,用NK-107树脂对SAP大鼠行血液灌流并测定血液中白细胞介素1(IL-l)、白细胞介素6(IL-6)及肿瘤坏死因子(TNF)的变化情况.结果:SAP大鼠血液中的IL-1、IL-6、TNF在发病早期可明显升高,通过血液灌流可使这些细胞因子的水平下降.从而使SAP大鼠的病死率由53.33%降至25.93%,存活时间平均由24.20±5.60小时延长至30.50±630小时.结论:NK-107树脂血液灌流对SAP有一定治疗作用.
The study on cytokines removal with NK-107 resin hemoperfusion in severe acute pancreatitis (SAP) was reported. The SAP model rats were established with injection of sodium tau-rocholate. The IL-1, IL-6 and TNF increased in the early stage. The cytokines were decreased by hemoperfusion in SAP rats, and the survival rate and survival time were improved.
出处
《生物医学工程与临床》
CAS
1998年第3期158-160,共3页
Biomedical Engineering and Clinical Medicine
