α干扰素治疗慢性乙型肝炎前后血清PC Ⅲ和HA水平的变化

CHANGES OF SERUM TYPE Ⅲ PROCOLLAGEN AND HYALURONIC ACID LEVELS IN PATIENTS WITH CHRONIC HEPATITIS B BEFORE AND AFTER TREATMENT WITH INTERFERON-a

用α干扰素治疗慢性乙型肝炎31例,检测了治疗前后血清Ⅲ型前胶原(PCⅢ)和透明质酸(HA)的含量变化。结果,治疗组疗程结束后血清PCⅢ和HA含量显著降低,而对照组无显著性变化;血清HBV DNA阴转者血清PCⅢ和HA水平明显低于未阴转者,表明α干扰素可减轻慢性乙型肝炎患者肝纤维化的程度及活动性,其抗肝纤维化作用与抗病毒作用密切相关。

In this paper, 31 patients with chronic hepatitis B were treated with interferon ct-2b and their serum type Ⅲ procollagen (PCⅢ) and hyaluronic acid (HA) levels were detected before and after the treatment.The results showed that the serum PCⅢ and HA levels in the treatment group decreased significantly at the end of the treatment while no significant changes in the control group.6 patients in the treatment group with negative serum HBV DNA at the end of interferon therapy had significantly lower PCⅢ and HA levels than those still with positive HBV DNA.Our results suggest that interferon-a can inhibit fibrotic proliferation in patients with chronic hepatits B, and this anti-fibrotic activity may be closely related to its anti-viral function.