庚型肝炎病毒感染的初步调查

SEROLOGICAL INVESTIGATION OF ANTI-HGV IN PATIENTS WITH VIRAL HEPATITIS

采用酶联免疫法(ELISA)检测94例病毒性肝炎患者血清中抗庚型肝炎病毒抗体(抗-HGV),阳性率为23.4％。其中急性肝炎、慢性肝炎、重型肝炎抗-HGV阳性率分别为21.4％、21.1％、30.4％,在22例抗-HGV阳性病人中,HBV与HGV重叠感染率为36.3％。39例非甲-戊型肝炎抗HGV的阳性率(35.5％)明显高于55例乙型肝炎的阳性率(14.5％、P<0.05),说明HGV感染主要存在于非甲-戊型肝炎病人中。23例重型肝炎中有16例死亡,抗HGV(+)7例全部死亡,而单纯HBV感染的死亡率为56.25％。结果显示:HGV感染系非甲-戊型肝炎的主要原因,HGV可以与HBV重叠感染,且可能影响重型肝炎的愈后。

Serum samples from 94 patients with viral hepatitis were tested for anti-HGV by enzyme-linked immunosorbent assay (EL1SA).Among the 94 cases, the serum anti-HGV positive rate was 23.4%.The serum anti-HGV positive rates in acute hepatitis, chronic hepatitis and severe hepatitis were 21.' 4% ,21.1 % and 30.4% , respectively.The serum anti-HGV positive rate in 39 cases with non A-E hepatitis was much higher than in 55 cases with hepatitis B( 14.5%).The mortality rates of patients with anti-HGV positive severe hepatitis and of those with HBV infection alone were 100% and 56.25%.The results suggest that HGV infection is an important etiologic agent for non-A-E viral hepatitis.HGV and HBV may be co-infected which might influence the prognosis of severe hepatitis.