体外循环心不停跳心内手术对RAAS的影响研究

THE RESEARCH OF EFFECT ON RENINANGIOTENSINALDOSTERONE SYSTEM(RAAS) IN BEATING HEART SURGERY DURING CARDIOPULMONARY BYPASS

目的：研究体外循环心脏不停跳手术及停跳手术对ＲＡＡＳ的影响的差异。方法：采用放射免疫分析法对３０例体外循环心脏不停跳心内手术及１２例心脏停跳手术患者手术前后的肾素（ＰＲＡ），血管紧张素Ⅱ（ＡⅡ），醛固酮（Ａｌｄｏ）及平均动脉压（ＭＡＰ）进行比较。结果：不停跳手术患者血浆ＰＲＡ、ＡⅡ、Ａｌｄｏ均较停跳组恢复至正常水平所需时间短，两组患者ＭＡＰ水平无差异。

Objective:To study the different of the effect on RAAS in beating heart surgery and cardioplegia surgery during CPBMethods:Preand postoperative charges of plasma renin activity(PRA),angiotensin Ⅱ(AⅡ),aldosterone(Aldo),mean arterial pressure(MAP) are measured by radioimmunoassay in 12 cardioplegia surgery and in 30 beating heart surgery during Cardiopulmonary Bypass (CPB)Results:The comparison of the result show that it needs less time to recover PRA、AⅡ、Aldo in beating heart surgery during CPB to normal level than that in cardioplegia surgery,the level of MAP in both cases have no differenceConclusion:These imply that the effect on RAAS in beating heart surgery during CPB is less than that in cardioplegia surgery