脑创伤大鼠全身及呼吸系统免疫功能的改变

THE EFFECTS OF HEAD TRAUMA ON SYSTEMIC IMMUNITY AND RESPIRATORY TRACT IMMUNITY IN RAT

目的：探讨脑创伤后易合并继发感染的原因。方法：对５０只人为造成脑创伤组大鼠和５０只对照组大鼠进行了多项免疫功能的检测。结果：①脑创伤大鼠肺泡巨噬细胞吞噬率、肺门淋巴结特异性玫瑰花环形成率和肺泡Ｔ淋巴细胞百分比均明显低于对照组，但其肺泡中中性粒细胞（ＰＭＮ）数目显著高于对照组；②脑创伤大鼠外周血ＰＭＮ吞噬率、脾细胞特异性玫瑰花环形成率和外周血Ｔ淋巴细胞百分比均明显低于对照组，但其外周血白细胞移行抑制指数显著高于对照组。

Objective:To study the causes of secondary infectionafter head traumaMethods:The respiratory tract immunity and systemic immunity were determined in 50 rats suffering from head trauma and 50 control ratsResults:①the effects of head trauma on the respiratory tract immunity were as follows:the AM phagocytic rate,the number of lung lymph node lymphocyte rossette formation,and the percentage of the peripheral blood T cells were significantly decreased in the head trauma groupThe number ofthe lung PMN was significantly higher in the head trauma group than that of the control group;②the effects of head trauma on the systemic immunity were as follows,the phagocytic function of the peripheral blood PMN,percentage of T cells,and the number of splenocyte rosette formation decreased significantly in head trauma groupThe index of MIT in the head trauma group was significantly higher than that of the control groupConclusion:The functional state of the immune system,including the local respiratory immunological functions and the systemic immunological functions,is inhibited by head trauma.Such immunological dyfunction may be one of the mechanisms leading to the predispostion of patients with head trauma to secondary infection,especially secondary infection of the respiratory tract